Advantages of using animal models in toxicology. A variety .

Advantages of using animal models in toxicology. The use of disease models would permit evaluation of efficacy and toxicity in the same animals. Sep 17, 2023 · As described by , the use of animal models of disease in routine toxicology studies may be a beneficial approach but is not without its drawbacks. Toxicologists are involved in the evaluation of household products, medicines and the effects of incidental and occupational exposure to natural and manufactured substances. . In toxicology, they are also the first species to be considered for in vivo toxicity and combined efficacy/toxicity studies. Animal testing remains a necessary tool for understanding the effects of various substances on living organisms. This review provides an overview on the applications of transgenic animal models in the assessment of mutagenicity and carcinogenicity, their use as reporter systems, and as tools for understanding the roles of xenobiotic-metabolizing enzymes and biological receptors in the etiology of chemical toxicity. The rationale for using animal models in toxicology plays a crucial role in bridging the gap between theoretical research and practical applications. Chapter 8 discusses how those approaches might lead to improved qualitative and quantitative risk assessment. Toxicology testing is a crucial step in the development and safety assessment of new chemicals, pharmaceuticals, and other products. 0thz0jb 2ghk tf kgdatsw es wu2h hb qpz le4x fji